Cisplatin induced hypocalcemia

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August undefined, 2024

WebBoldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats: Role of oxidative stress, inflammation and caspase-3 WebFeb 17, 2024 · A number of drugs sometimes cause hypocalcemia as a side effect. Some of these include the following: Certain drugs for osteoporosis ( bisphosphonates like zoledronate) 5 Some antiepileptic drugs Certain chemotherapy drugs (like cisplatin) Diuretic drugs (like furosemide) 6 Proton pump inhibitors

Hypocalcemia Article - StatPearls

WebApr 15, 2024 · Neurologically, very severe hypophosphatemia (<0.6 mg/dL) can contribute to paresthesia, altered mental status, encephalopathy, seizures and coma [ 14 ]. Depletion of ATP in the heart can result in depression of myocardial performance and tachyarrhythmias in patients with serum phosphate ˂1.5 mg/dL [ 15 ]. WebNov 7, 2012 · The cisplatin-induced increase of the Kim-1 expression level suggests that the PST segment is also affected in our study [30, 44]. The NHE3 expression levels were similar in the kidneys of control and cisplatin-treated groups. ... Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the … how much money is a bodyguard

DRUG NAME: Cisplatin - BC Cancer

WebJul 24, 2024 · Cisplatin, a chemotherapeutic drug, can also cause hypocalcemia through hypomagnesemia. Foscarnet can cause … WebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … WebSep 4, 2009 · It should be noted that cisplatin causes hypocalcemia in a dose-dependent manner. Indeed, hypocalcemia is a frequent adverse effect of high-dose cisplatin … how do i say it\\u0027s a beau

A review of drug-induced hypocalcemia SpringerLink

Refractory potassium repletion due to cisplatin-induced

WebHypocalcemia is uncommon and has been attributed to hypomagnesemia resulting from use of a chemotherapeutic regimen. Very few publications have described … WebThese effects are due to renal tubular damage. Cisplatin greatly increases the urinary excretion of magnesium and calcium; increased excretion of potassium, zinc, copper and … how much money is a budgieWebJul 18, 2024 · Cisplatin causes hypomagnesemia in a dose-dependent fashion and affects up to 90% of patients if no preventive measures are taken (see Section 5 below). 79 The etiology of cisplatin-induced hypomagnesemia is not completely understood; renal Mg loss is the primary mechanism, but gastrointestinal losses have also been reported. 80 … how do i say it is what it is in spanish

"WebMar 9, 2024 · Cisplatin is a clinically advanced and highly effective anticancer drug that is used for the treatment of various solid tumors, such as lung cancer, stomach cancer, and ovarian cancer [1]. However, nephrotoxicity is the … " - Cisplatin induced hypocalcemia

Cisplatin induced hypocalcemia

Hypocalcemia: Symptoms, Causes, Diagnosis, and Treatment - Verywell Health

Webmannitol, or furosemide-induced diuresis is used t o effectively decrease cisplatin-induced nephrotoxicity. 7. Lower doses of cisplatin are given with less intensive hydration. For example, patients receiving doses of 35 mg/m. 2 . ... hypocalcemia may become symptomatic, with muscle irritability or cramps, clonus, tremor, carpopedal spasm and ... WebHypomagnesemia is a common side effect of cisplatin occurring . in 90% of patients by the fourth cycle of treatment caused by renal tubular damage leading to increased renal …

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http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf

WebCisplatin-induced hypomagnesemia with seizures: a case report and review of the literature Gynecol Oncol. 1988 May;30(1):104-13. doi: 10.1016/0090-8258(88)90052-2. Authors S L Bellin 1 ... Hypocalcemia / chemically induced Hypokalemia / … WebMay 10, 2006 · Hypomagnaesemic induced hypocalcaemia is caused by inhibition of parathyroid hormone secretion, impaired calcium release from the bones and low tissue responses to PTH due to low magnesium levels. Cisplatin associated hypocalcaemia and hypercalciuria can not be influenced by calcium supplementation.

WebJul 24, 2024 · Cisplatin, a chemotherapeutic drug, can also cause hypocalcemia through hypomagnesemia. Foscarnet can cause hypocalcemia by forming complexes with ionized calcium, thereby reducing levels of ionized calcium. It is therefore important to regularly monitor calcium levels during treatment with all of the above-mentioned drugs. [8] [9] WebJul 19, 2024 · Usually, the hypocalcemia is resistant to calcium or vitamin D therapy. Normocalcemia and relief of clinical symptoms can be attained by administration of high oral doses of magnesium, up to 20 times the normal intake. ... Cisplatin- and amphotericin B–induced magnesium deficiency is associated with hypocalciuria, which suggests …

WebJul 18, 2024 · Cisplatin causes hypomagnesemia in a dose-dependent fashion and affects up to 90% of patients if no preventive measures are taken (see Section 5 below). 79 The …

WebMay 24, 2006 · Cisplatin is the most commonly used antineoplastic agent for the treatment of solid tumors and is a well-known cause of nephrotoxicity [ 1 ]. In this study we report a case with chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria 20 years after the initial treatment with cisplatin therapy. how much money is a bugatti chironWebDec 26, 2024 · Phosphate is one of the most important molecular elements to normal cellular functions within the body. It acts as an integral component of nucleic acids and is used to replicate DNA and RNA. It is an energy … how do i say it\\u0027s a beautiful day in swedWebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced … how do i say idiot in spanishhttp://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf how do i say interpreter in spanishWebElectrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management. Platinum chemotherapy, particularly cisplatin, is commonly associated with … how do i say it\\u0027s a beaut spanishWebApr 10, 2024 · Med-Surg Nursing. Hypocalcemia is when there are low levels of calcium in the blood. Calcium is an electrolyte that plays a vital role in many bodily functions, including muscle contraction, nerve transmission, and bone formation. Various factors, including nutritional deficiencies, medications, and underlying medical conditions, can all lead ... how do i say it\\u0027s a beautiful day in swediWebCisplatin is a well-known chemotherapeutic agent that can be associated with hyponatremia. Mechanisms of cisplatin-induced hyponatremia include renal salt wasting syndrome (RSWS), and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) (Cheng et al., 2011 ). how do i say it\u0027s a beautiful day